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It is thought to influence the sleep-wake cycle by affecting neurotransmitter activity, including that of gamma-aminobutyric acid (GABA) and serotonin

High-amplitude pulses, as facilitated by GHS-R1a activation, maximize the nuclear translocation of STAT5b, which is a primary driver of IGF-1 mRNA expression and lipid metabolism genes

A deficiency can also cause issues such as diarrhea, nausea, vomiting, lack of appetite, weight loss, pale skin, numbness and tingling in your hands and feet, confusion, irritability, depression, and behavior changes